What does asbestos have to do with mesothelioma?
The only known cause of mesothelioma in the United States is previous
exposure to asbestos fibers. Asbestos manufacturers knew about the hazards of
asbestos seventy years ago - but they kept this knowledge to themselves. The
first warnings given to workers exposed to asbestos were in the mid-1960s, and
they were terribly inadequate. Even today, workers are not always told they are
working around asbestos and are at risk for asbestos disease.
What can someone with mesothelioma do?
- Seek out the best and most up-to-date information.
- Seek out the best medical care.
- Early screening for mesothelioma diagnosis.
- Stay in close contact with your doctor.
- Consider whether or not you want to bring a lawsuit because of this
asbestos-related injury.
- Remember that resources are available to you through community and
medical support groups, asbestos victims' organizations, your place of
worship, as well as your family and friends.
How common is mesothelioma?
Although reported incidence rates have increased in the past 20 years,
mesothelioma is still a relatively rare cancer. About 2,000 new cases of
mesothelioma are diagnosed in the United States each year. Mesothelioma occurs
more often in men than in women and risk increases with age, but this disease
can appear in either men or women at any age.
What are the risk factors for mesothelioma?
Working with asbestos is the major risk factor for mesothelioma. A history of
asbestos exposure at work is reported in about 70 percent to 80 percent of all
cases. However, mesothelioma has been reported in some individuals without any
known exposure to asbestos.
Asbestos is the name of a group of minerals that occur naturally as masses of
strong, flexible fibers that can be separated into thin threads and woven.
Asbestos has been widely used in many industrial products, including cement,
brake linings, roof shingles, flooring products, textiles, and insulation. If
tiny asbestos particles float in the air, especially during the manufacturing
process, they may be inhaled or swallowed, and can cause serious health
problems. In addition to mesothelioma, exposure to asbestos increases the risk
of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other
cancers, such as those of the larynx and kidney.
Smoking does not appear to increase the risk of mesothelioma. However, the
combination of smoking and asbestos exposure significantly increases a person's
risk of developing cancer of the air passageways in the lung.
Who is at increased risk for developing mesothelioma?
Asbestos has been mined and used commercially since the late 1800s. Its use
greatly increased during World War II. Since the early 1940s, millions of
American workers have been exposed to asbestos dust. Initially, the risks
associated with asbestos exposure were not known. However, an increased risk of
developing mesothelioma was later found among shipyard workers, people who work
in asbestos mines and mills, producers of asbestos products, workers in the
heating and construction industries, and other tradespeople. Today, the U.S.
Occupational Safety and Health Administration (OSHA) sets limits for acceptable
levels of asbestos exposure in the workplace. People who work with asbestos wear
personal protective equipment to lower their risk of exposure.
The risk of asbestos-related disease increases with heavier exposure to
asbestos and longer exposure time. However, some individuals with only brief
exposures have developed mesothelioma. On the other hand, not all workers who
are heavily exposed develop asbestos-related diseases.
There is some evidence that family members and others living with asbestos
workers have an increased risk of developing mesothelioma, and possibly other
asbestos-related diseases. This risk may be the result of exposure to asbestos
dust brought home on the clothing and hair of asbestos workers. To reduce the
chance of exposing family members to asbestos fibers, asbestos workers are
usually required to shower and change their clothing before leaving the
workplace.
People considering clinical trials may be interested in the NCI booklet
Taking Part in Clinical Trials: What Cancer Patients Need To Know. This booklet
describes how research studies are carried out and explains their possible
benefits and risks. The booklet is available by calling the CIS, or from the NCI
Publications Locator Web site at
http://cancer.gov/publications on the Internet.
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Mesothelioma:
Questions and Answers - Part 7b
Chemotherapy is the use of
anticancer drugs to kill cancer cells throughout the body. Most drugs used to
treat Mesothelioma are given by injection into a vein (intravenous, or IV).
Doctors are also studying the effectiveness of putting chemotherapy directly
into the chest or abdomen (intracavitary chemotherapy). To relieve symptoms and
control pain, the doctor may use a needle or a thin tube to drain fluid that has
built up in the chest or abdomen. The procedure for removing fluid from the
chest is called thoracentesis. Removal of fluid from the abdomen is called
paracentesis. Drugs may be given through a tube in the chest to prevent more
fluid from accumulating. Radiation therapy and surgery may also be helpful in
relieving symptoms.
##
Mesothelioma:
Questions and Answers
Mesothelioma - Are New
Treatments for Mesothelioma Being Studied? - Part 8a
Yes.
Because Mesothelioma is very hard to control, the National Cancer Institute
(NCI) is sponsoring clinical trials (research studies with people) that are
designed to find new treatments and better ways to use current treatments.
Before any new treatment can be recommended for general use, doctors conduct
clinical trials to find out whether the treatment is safe for patients and
effective against the disease. Participation in clinical trials is an important
treatment option for many patients with Mesothelioma.
People interested in taking part in a clinical trial should talk with their
doctor. Information about clinical trials is available from the Cancer
Information Service (CIS) (see below) at 1 800 4 CANCER. Information specialists
at the CIS use PDQ ®, NCI's cancer information database, to identify and provide
detailed information about specific ongoing clinical trials. Patients also have
the option of searching for clinical trials on their own.
Mesothelioma
How
is mesothelioma treated?
Treatment for mesothelioma
depends on the location of the cancer, the stage of the disease, and the
patient's age and general health. Standard treatment options include surgery,
radiation therapy, and chemotherapy. Sometimes, these treatments are combined.
Surgery is a common treatment for mesothelioma. The doctor may remove part of
the lining of the chest or abdomen and some of the tissue around it. For cancer
of the pleura (pleural mesothelioma), a lung may be removed in an operation
called a pneumonectomy. Sometimes part of the diaphragm, the muscle below the
lungs that helps with breathing, is also removed.
Radiation therapy, also called radiotherapy, involves the use of high-energy
rays to kill cancer cells and shrink tumors. Radiation therapy affects the
cancer cells only in the treated area. The radiation may come from a machine
(external radiation) or from putting materials that produce radiation through
thin plastic tubes into the area where the cancer cells are found (internal
radiation therapy).
Chemotherapy is the use of anticancer drugs to kill cancer cells throughout the
body. Most drugs used to treat mesothelioma are given by injection into a vein
(intravenous, or IV). Doctors are also studying the effectiveness of putting
chemotherapy directly into the chest or abdomen (intracavitary chemotherapy). To
relieve symptoms and control pain, the doctor may use a needle or a thin tube to
drain fluid that has built up in the chest or abdomen. The procedure for
removing fluid from the chest is called thoracentesis. Removal of fluid from the
abdomen is called paracentesis. Drugs may be given through a tube in the chest
to prevent more fluid from accumulating. Radiation therapy and surgery may also
be helpful in relieving symptoms.
Mesothelioma -
Lung Cancer Link - Part 3
Konstantin Chumakov of the FDA
Center for Biologics Evaluation and Research, says that Carbone's findings leave
many unanswered questions. For example, he said it is not clear from the
labeling of the samples found at the NIBSC exactly when they were used in the
Soviet Union or for how long. Chumakov, whose father was director of the Soviet
Institute of Poliomyelitis Research during the time of the contamination, says
he was told that at one point the Soviet Union was supplying more than 100
countries with its vaccine.
He traveled to Moscow in April 2004 to try to learn more about the production
and testing of the Soviet vaccine. But he found no more vaccine samples from
that era, and very little surviving documentation about specific batches and why
they might have been contaminated. "It's hard to explain how it happened," he
says, "but it obviously did."
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